Both prescription and nonprescription nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to be effective for many people with psoriatic arthritis (PsA). Although they will not cure the disease, doctors often use them as their first choice of treatment, because NSAIDs can control swelling and inflammation and help to alleviate the pain and morning stiffness often associated with psoriatic arthritis. NSAID therapy may also lead to improvements in the range of motion of affected joints, which may help reduce the restrictions on daily activities often caused by psoriatic arthritis.
NSAIDs are available as oral tablets and capsules or as a liquid. They include over-the-counter medications, such as aspirin, ibuprofen (Advil®, Motrin®), and naproxen (Aleve®, Naprosyn®), as well as more potent prescription versions such as indomethacin (Indocin®). Because so many NSAIDs are available in varying strengths and dosage regimens, choosing the appropriate one is a decision to be made with your doctor.
How NSAIDs Work
NSAIDs work by inhibiting the cyclo-oxygenase (COX-1 and COX-2) enzymes. Both the COX-1 and COX-2 enzymes are involved in the production of prostaglandins, which are hormone-like substances produced in various tissues. They mediate a range of physiological functions, such as metabolism and nerve transmissions.
Copyright 2009 NBC Health
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